Title |
Single dose of Glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses
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Published in |
Virology Journal, October 2013
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DOI | 10.1186/1743-422x-10-317 |
Pubmed ID | |
Authors |
Arun V Iyer, Bapi Pahar, Vladimir N Chouljenko, Jason D Walker, Brent Stanfield, Konstantin G Kousoulas |
Abstract |
Herpes simplex virus type-1(HSV-1) and HSV-2 are important human pathogens that cause significant ocular and urogenital complications, respectively. We have previously shown that HSV-1 virions lacking glycoprotein K (gK) are unable to enter into neurons via synaptic axonal membranes and be transported in either retrograde or anterograde manner. Here, we tested the ability of HSV-1 (F) gK-null to protect against lethal challenge with either highly virulent ocular HSV-1 (McKrae strain), or genital HSV-2 (G strain). The gK-null virus vaccine efficiently protected mice against lethal vaginal infection with either HSV-1(McKrae) or HSV-2 (G). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 36% |
Researcher | 3 | 21% |
Student > Master | 1 | 7% |
Student > Ph. D. Student | 1 | 7% |
Professor > Associate Professor | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 21% |
Biochemistry, Genetics and Molecular Biology | 3 | 21% |
Immunology and Microbiology | 3 | 21% |
Veterinary Science and Veterinary Medicine | 1 | 7% |
Medicine and Dentistry | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 21% |