Title |
Augmentation of 5-lipoxygenase activity and expression during dengue serotype-2 infection
|
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Published in |
Virology Journal, October 2013
|
DOI | 10.1186/1743-422x-10-322 |
Pubmed ID | |
Authors |
Wai Mun Loke, Angelia Yee Chow, Karen Lam Mok Sing, Chung-Yung J Lee, Barry Halliwell, Erle CH Lim, Amy ML Quek, Eng Eong Ooi, Raymond CS Seet |
Abstract |
Leukotriene B4, a 5-lipoxygenase product of arachidonic acid with potent chemotactic effects on neutrophils, has not been assessed in dengue patients. In this study, plasma leukotriene B4 and serum high-sensitivity C-reactive protein levels were determined in adult patients during the febrile, convalescent and defervescent stages of dengue serotype-2 (DENV-2) infection, and compared with those of age-matched healthy and non-dengue febrile subjects. In vitro studies were performed to examine the effects of live and heat-inactivated DENV-2 on the activities and expression of 5-lipoxygenase in human neutrophils. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 11 | 24% |
Researcher | 7 | 15% |
Student > Bachelor | 7 | 15% |
Student > Ph. D. Student | 6 | 13% |
Professor > Associate Professor | 3 | 7% |
Other | 6 | 13% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 14 | 30% |
Medicine and Dentistry | 9 | 20% |
Immunology and Microbiology | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Sports and Recreations | 2 | 4% |
Other | 5 | 11% |
Unknown | 10 | 22% |