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Brain structural investigation and hippocampal tractography in medication overuse headache: a native space analysis

Overview of attention for article published in Behavioral and Brain Functions, April 2017
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Title
Brain structural investigation and hippocampal tractography in medication overuse headache: a native space analysis
Published in
Behavioral and Brain Functions, April 2017
DOI 10.1186/s12993-017-0124-5
Pubmed ID
Authors

M. Meyer, G. Di Scala, M. Edde, B. Dilharreguy, F. Radat, M. Allard, S. Chanraud

Abstract

Spatial normalization of brain images, a prerequisite for voxel based morphometry analysis, may account for the large variability of the volumetric data in medication overuse headache (MOH); possibly because this disease concerns patients differing on both sex and age, and hence with different brain size and shape. The present study aimed at providing a subject-based analysis of macrostructure using a native space volumes segmentation (Freesurfer), and microstructure using a region of interest (ROI: i.e. hippocampus) tractography approach in MOH patients. The results show that MOH patients had decreased volumes of left hemisphere temporal gyri (temporal superior, fusiform) and occipital middle gyrus, together with an increased volume of the left inferior (temporal) lateral ventricle. The left temporal volume was negatively correlated with depression score and medication dependence parameters. Seed-based tractography of the hippocampus revealed a decreased number of reconstructed fibers passing through the left hippocampus. To our knowledge, these alterations have not been described with methods involving brain normalization, and they indicate that left hemisphere temporal areas, including the hippocampus, may play a role in MOH pathophysiology. Trial registration number NCT00833209. Registered 29 January 2009.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 18%
Student > Ph. D. Student 5 15%
Student > Master 5 15%
Student > Bachelor 4 12%
Other 4 12%
Other 2 6%
Unknown 8 24%
Readers by discipline Count As %
Neuroscience 7 21%
Psychology 4 12%
Agricultural and Biological Sciences 3 9%
Nursing and Health Professions 3 9%
Social Sciences 3 9%
Other 5 15%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2017.
All research outputs
#18,541,268
of 22,963,381 outputs
Outputs from Behavioral and Brain Functions
#288
of 392 outputs
Outputs of similar age
#235,715
of 309,848 outputs
Outputs of similar age from Behavioral and Brain Functions
#5
of 5 outputs
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