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Tumor hypoxia as a driving force in genetic instability

Overview of attention for article published in Genome Integrity, October 2013
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1 X user

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Title
Tumor hypoxia as a driving force in genetic instability
Published in
Genome Integrity, October 2013
DOI 10.1186/2041-9414-4-5
Pubmed ID
Authors

Kaisa R Luoto, Ramya Kumareswaran, Robert G Bristow

Abstract

Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has an adverse impact on patient prognosis. Tumor hypoxia can increase metastatic capacity and lead to resistance to chemotherapy and radiotherapy. Hypoxia also leads to altered transcription and translation of a number of DNA damage response and repair genes. This can lead to inhibition of recombination-mediated repair of DNA double-strand breaks. Hypoxia can also increase the rate of mutation. Therefore, tumor cell adaptation to the hypoxic microenvironment can drive genetic instability and malignant progression. In this review, we focus on hypoxia-mediated genetic instability in the context of aberrant DNA damage signaling and DNA repair. Additionally, we discuss potential therapeutic approaches to specifically target repair-deficient hypoxic tumor cells.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
United Kingdom 1 <1%
Unknown 189 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 21%
Researcher 28 14%
Student > Master 25 13%
Student > Bachelor 23 12%
Student > Doctoral Student 11 6%
Other 22 11%
Unknown 44 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 54 28%
Agricultural and Biological Sciences 39 20%
Medicine and Dentistry 29 15%
Chemistry 5 3%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 15 8%
Unknown 47 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2013.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Genome Integrity
#24
of 38 outputs
Outputs of similar age
#169,429
of 224,529 outputs
Outputs of similar age from Genome Integrity
#1
of 1 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 38 research outputs from this source. They receive a mean Attention Score of 3.9. This one scored the same or higher as 14 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,529 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them