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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Tumor hypoxia as a driving force in genetic instability
|
|---|---|
| Published in |
Genome Integrity, January 2013
|
| DOI | 10.1186/2041-9414-4-5 |
| Pubmed ID | |
| Authors |
Kaisa R Luoto, Ramya Kumareswaran, Robert G Bristow |
| Abstract |
Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has an adverse impact on patient prognosis. Tumor hypoxia can increase metastatic capacity and lead to resistance to chemotherapy and radiotherapy. Hypoxia also leads to altered transcription and translation of a number of DNA damage response and repair genes. This can lead to inhibition of recombination-mediated repair of DNA double-strand breaks. Hypoxia can also increase the rate of mutation. Therefore, tumor cell adaptation to the hypoxic microenvironment can drive genetic instability and malignant progression. In this review, we focus on hypoxia-mediated genetic instability in the context of aberrant DNA damage signaling and DNA repair. Additionally, we discuss potential therapeutic approaches to specifically target repair-deficient hypoxic tumor cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 192 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| United Kingdom | 1 | <1% |
| Unknown | 187 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 21% |
| Researcher | 27 | 14% |
| Student > Master | 25 | 13% |
| Student > Bachelor | 23 | 12% |
| Student > Doctoral Student | 11 | 6% |
| Other | 22 | 11% |
| Unknown | 44 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 52 | 27% |
| Agricultural and Biological Sciences | 39 | 20% |
| Medicine and Dentistry | 29 | 15% |
| Chemistry | 5 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 15 | 8% |
| Unknown | 47 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2013.
All research outputs
#19,895,107
of 24,451,065 outputs
Outputs from Genome Integrity
#23
of 37 outputs
Outputs of similar age
#226,837
of 289,332 outputs
Outputs of similar age from Genome Integrity
#2
of 2 outputs
Altmetric has tracked 24,451,065 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 37 research outputs from this source. They receive a mean Attention Score of 3.8. This one scored the same or higher as 14 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,332 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.