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Tumor hypoxia as a driving force in genetic instability

Overview of attention for article published in Genome Integrity, January 2013
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1 tweeter

Citations

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183 Mendeley
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Title
Tumor hypoxia as a driving force in genetic instability
Published in
Genome Integrity, January 2013
DOI 10.1186/2041-9414-4-5
Pubmed ID
Authors

Kaisa R Luoto, Ramya Kumareswaran, Robert G Bristow

Abstract

Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has an adverse impact on patient prognosis. Tumor hypoxia can increase metastatic capacity and lead to resistance to chemotherapy and radiotherapy. Hypoxia also leads to altered transcription and translation of a number of DNA damage response and repair genes. This can lead to inhibition of recombination-mediated repair of DNA double-strand breaks. Hypoxia can also increase the rate of mutation. Therefore, tumor cell adaptation to the hypoxic microenvironment can drive genetic instability and malignant progression. In this review, we focus on hypoxia-mediated genetic instability in the context of aberrant DNA damage signaling and DNA repair. Additionally, we discuss potential therapeutic approaches to specifically target repair-deficient hypoxic tumor cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
United Kingdom 1 <1%
Unknown 178 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 21%
Researcher 26 14%
Student > Master 24 13%
Student > Bachelor 22 12%
Student > Doctoral Student 10 5%
Other 23 13%
Unknown 39 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 50 27%
Agricultural and Biological Sciences 38 21%
Medicine and Dentistry 28 15%
Chemistry 5 3%
Engineering 5 3%
Other 17 9%
Unknown 40 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2013.
All research outputs
#18,351,676
of 22,727,570 outputs
Outputs from Genome Integrity
#21
of 30 outputs
Outputs of similar age
#218,074
of 280,760 outputs
Outputs of similar age from Genome Integrity
#2
of 2 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 30 research outputs from this source. They receive a mean Attention Score of 3.7. This one scored the same or higher as 9 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,760 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.