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Rubella Seroprevalence and real-time PCR detection of RUBV among Congolese pregnant women

Overview of attention for article published in BMC Infectious Diseases, April 2017
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Title
Rubella Seroprevalence and real-time PCR detection of RUBV among Congolese pregnant women
Published in
BMC Infectious Diseases, April 2017
DOI 10.1186/s12879-017-2352-6
Pubmed ID
Authors

Josue Zanga, Makola Kennedy Mbanzulu, Arnold-Freddy Kabasele, Nlandu Roger Ngatu, Dimosi Roger Wumba

Abstract

Rubella is an acute infectious disease caused by Rubella virus (RUBV). RUBV remains an important pathogen worldwide, causing approximately 100 000 cases of congenital rubella syndrome (CRS) every year; and the most severe consequence of rubella is teratogenicity. The aim of this study was to estimate the prevalence of RUBV IgG antibodies and determine RUBV genotypes in Congolese pregnant women in Kongo central province, Democratic Republic of Congo (DRC). This was a prospective cross-sectional study that consisted of a laboratory analysis of blood samples from 78 pregnant women to check for the presence of RUBV IgG antibodies, and also determine RUBV genotypes in seropositive samples (using primers targeting RUBV nucleoprotein), with the use of serological and molecular methods, respectively. Participants were pregnant women attending antenatal care clinics (ANC) at two health zones of Kisantu town in DRC. They were followed-up from the first to third trimester. Those who were negative for RUBV antibodies at the initial assay (first trimester) were tested in the second and, eventually, the third trimester. An overall rubella seroprevalence of 58.97% was observed, whereas RUBV nucleoprotein was detected in 60% of randomly selected 30 blood samples among the 46 RUBV seropositive pregnant women. Five (27.77%) of positive samples were positive for both RUBV genotypes (RV8633/9112 and RV8945/9577), whereas 11 (61.11%) of them were positive for RV8633/9112 and two (11.11%) were positive for RV8945/9577 only. Regarding rubella clinical signs and complications, two subjects (2.56%) presented with fever, whereas five pregnant women (6.41%) had experienced abortion. None (0%) of the participants has been vaccinated against RUBV. Findings from this study suggest that RUBV is prevalent in Congolese pregnant women. Further research is required to elucidate the molecular epidemiology of RUBV in order to design a rational rubella surveillance and control program in DRC.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 61 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 30%
Researcher 6 10%
Student > Postgraduate 6 10%
Student > Doctoral Student 4 7%
Student > Bachelor 3 5%
Other 9 15%
Unknown 15 25%
Readers by discipline Count As %
Medicine and Dentistry 16 26%
Nursing and Health Professions 7 11%
Immunology and Microbiology 5 8%
Biochemistry, Genetics and Molecular Biology 5 8%
Agricultural and Biological Sciences 3 5%
Other 6 10%
Unknown 19 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2017.
All research outputs
#20,413,129
of 22,963,381 outputs
Outputs from BMC Infectious Diseases
#6,506
of 7,706 outputs
Outputs of similar age
#269,833
of 309,563 outputs
Outputs of similar age from BMC Infectious Diseases
#140
of 171 outputs
Altmetric has tracked 22,963,381 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,706 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.