Title |
IL-29 enhances Toll-like receptor-mediated IL-6 and IL-8 production by the synovial fibroblasts from rheumatoid arthritis patients
|
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Published in |
Arthritis Research & Therapy, October 2013
|
DOI | 10.1186/ar4357 |
Pubmed ID | |
Authors |
Lingxiao Xu, Xiaoke Feng, Wenfeng Tan, Weijuan Gu, Dunming Guo, Miaojia Zhang, Fang Wang |
Abstract |
We previously reported that IL-29, a newly described member of interferon (IFN) family, was overexpressed in blood and synovium of rheumatoid arthritis (RA) patients and triggered proinflammatory cytokine IL-6 and IL-8 mRNA expression in RA synovial fibroblasts (RA-FLS). This suggests that IL-29 has an important role in synovial inflammation. Toll-like receptors (TLRs) also activate RA-FLS to produce inflammatory mediators including tumor necrosis factor α (TNF-α) and IL-1β in RA-FLS. Since the TLR family plays an early role in the innate immune response and the subsequent induction of the adaptive immune response, we hypothesize that IL-29 interacts with TLRs in RA inflammation. This study aimed to investigate the effect of IL-29 on TLR-mediated proinflammatory cytokine production in RA-FLS. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 37 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 5 | 14% |
Student > Bachelor | 4 | 11% |
Other | 4 | 11% |
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