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Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study

Overview of attention for article published in Critical Care, October 2013
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32 Mendeley
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Title
Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study
Published in
Critical Care, October 2013
DOI 10.1186/cc13093
Pubmed ID
Authors

David Morritz de Kretser, Jonathan Guy Bensley, Ville Pettilä, Rita Linko, Mark Peter Hedger, Susan Hayward, Carolyn Anne Allan, Robert Ian McLachlan, Helen Ludlow, David James Phillips

Abstract

30 day mortality in patients with Acute Respiratory Failure (ARF) is approximately 30%, defined as patients requiring ventilator support for more than 6 hours. Novel biomarkers are needed to predict patient outcomes and to guide potential future therapies. The activins A and B, members of the Transforming Growth Factor β family of proteins, and their binding protein, follistatin, have recently been shown to be important regulators of inflammation and fibrosis but no substantial data are available concerning their roles in ARF.Our objectives were to evaluate whether the serum levels of activin A, B and follistatin are elevated in 518 patients with ARF from the FINNALI study compared the concentrations in 138 normal subjects that form a reference range.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 3%
Brazil 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 13%
Student > Ph. D. Student 3 9%
Student > Doctoral Student 3 9%
Student > Bachelor 3 9%
Student > Master 3 9%
Other 8 25%
Unknown 8 25%
Readers by discipline Count As %
Medicine and Dentistry 15 47%
Biochemistry, Genetics and Molecular Biology 4 13%
Agricultural and Biological Sciences 2 6%
Immunology and Microbiology 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 0 0%
Unknown 9 28%