Title |
Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study
|
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Published in |
Critical Care, October 2013
|
DOI | 10.1186/cc13093 |
Pubmed ID | |
Authors |
David Morritz de Kretser, Jonathan Guy Bensley, Ville Pettilä, Rita Linko, Mark Peter Hedger, Susan Hayward, Carolyn Anne Allan, Robert Ian McLachlan, Helen Ludlow, David James Phillips |
Abstract |
30 day mortality in patients with Acute Respiratory Failure (ARF) is approximately 30%, defined as patients requiring ventilator support for more than 6 hours. Novel biomarkers are needed to predict patient outcomes and to guide potential future therapies. The activins A and B, members of the Transforming Growth Factor β family of proteins, and their binding protein, follistatin, have recently been shown to be important regulators of inflammation and fibrosis but no substantial data are available concerning their roles in ARF.Our objectives were to evaluate whether the serum levels of activin A, B and follistatin are elevated in 518 patients with ARF from the FINNALI study compared the concentrations in 138 normal subjects that form a reference range. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Finland | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 30 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 13% |
Student > Ph. D. Student | 3 | 9% |
Student > Doctoral Student | 3 | 9% |
Student > Bachelor | 3 | 9% |
Student > Master | 3 | 9% |
Other | 8 | 25% |
Unknown | 8 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 47% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Agricultural and Biological Sciences | 2 | 6% |
Immunology and Microbiology | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 0 | 0% |
Unknown | 9 | 28% |