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Mendeley readers
| Title |
Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy
|
|---|---|
| Published in |
Malaria Journal, October 2013
|
| DOI | 10.1186/1475-2875-12-377 |
| Pubmed ID | |
| Authors |
Nancy O Duah, Sena A Matrevi, Dziedzom K de Souza, Daniel D Binnah, Mary M Tamakloe, Vera S Opoku, Christiana O Onwona, Charles A Narh, Neils B Quashie, Benjamin Abuaku, Christopher Duplessis, Karl C Kronmann, Kwadwo A Koram |
| Abstract |
With the introduction of artemisinin-based combination therapy (ACT) in 2005, monitoring of anti-malarial drug efficacy, which includes the use of molecular tools to detect known genetic markers of parasite resistance, is important for first-hand information on the changes in parasite susceptibility to drugs in Ghana. This study investigated the Plasmodium falciparum multidrug resistance gene (pfmdr1) copy number, mutations and the chloroquine resistance transporter gene (pfcrt) mutations in Ghanaian isolates collected in seven years to detect the trends in prevalence of mutations. |
Mendeley readers
The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Vietnam | 1 | <1% |
| Burkina Faso | 1 | <1% |
| Ghana | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 135 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 26 | 18% |
| Researcher | 21 | 15% |
| Student > Ph. D. Student | 20 | 14% |
| Student > Bachelor | 19 | 13% |
| Lecturer | 6 | 4% |
| Other | 25 | 18% |
| Unknown | 24 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 22% |
| Biochemistry, Genetics and Molecular Biology | 27 | 19% |
| Medicine and Dentistry | 15 | 11% |
| Immunology and Microbiology | 10 | 7% |
| Social Sciences | 6 | 4% |
| Other | 24 | 17% |
| Unknown | 28 | 20% |