Title |
Autoimmune hemolytic anemia associated with babesiosis
|
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Published in |
Biomarker Research, April 2017
|
DOI | 10.1186/s40364-017-0095-6 |
Pubmed ID | |
Authors |
Roshni Narurkar, Aleksandra Mamorska-Dyga, John C. Nelson, Delong Liu |
Abstract |
Babesiosis is endemic in selected areas in North America. Babesia infection is commonly associated with anemia, thrombocytopenia, hyponatremia and elevated liver enzymes. Autoimmune hemolytic anemia (AIHA) is known to be caused by parasitic and viral infections but has not been well characterized. We describe two cases diagnosed with babesiosis triggering severe AIHA. One case had history of splenectomy, and the other was an elderly patient. Older, immunocompromised and asplenic patients may be particularly at risk for post-babesiosis AIHA (PB-AIHA). The pathogenesis for conventional AIHA and PB-AIHA appears to be different, since splenectomy is a treatment for conventional AIHA, whereas PB-AIHA is seen more often in asplenic patients. Further investigation into this intriguing mechanism of host immune response to babesiosis may help to elucidate the overall mechanism of infection- triggered AIHA. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 9 | 29% |
Other | 4 | 13% |
Student > Bachelor | 3 | 10% |
Student > Doctoral Student | 2 | 6% |
Researcher | 2 | 6% |
Other | 4 | 13% |
Unknown | 7 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 29% |
Veterinary Science and Veterinary Medicine | 5 | 16% |
Nursing and Health Professions | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Social Sciences | 2 | 6% |
Other | 4 | 13% |
Unknown | 7 | 23% |