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Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

Overview of attention for article published in Alzheimer's Research & Therapy, January 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)

Mentioned by

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1 tweeter
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1 patent

Citations

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62 Dimensions

Readers on

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166 Mendeley
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Title
Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets
Published in
Alzheimer's Research & Therapy, January 2013
DOI 10.1186/alzrt214
Pubmed ID
Authors

Amy M Pooler, Manuela Polydoro, Susanne Wegmann, Samantha B Nicholls, Tara L Spires-Jones, Bradley T Hyman

Abstract

Accumulation and aggregation of the microtubule-associated protein tau are a pathological hallmark of neurodegenerative disorders such as Alzheimer's disease (AD). In AD, tau becomes abnormally phosphorylated and forms inclusions throughout the brain, starting in the entorhinal cortex and progressively affecting additional brain regions as the disease progresses. Formation of these inclusions is thought to lead to synapse loss and cell death. Tau is also found in the cerebrospinal fluid (CSF), and elevated levels are a biomarker for AD. Until recently, it was thought that the presence of tau in the CSF was due to the passive release of aggregated tau from dead or dying tangle-bearing neurons. However, accumulating evidence from different AD model systems suggests that tau is actively secreted and transferred between synaptically connected neurons. Transgenic mouse lines with localized expression of aggregating human tau in the entorhinal cortex have demonstrated that, as these animals age, tau becomes mislocalized from axons to cell bodies and dendrites and that human tau-positive aggregates form first in the entorhinal cortex and later in downstream projection targets. Numerous in vitro and in vivo studies have provided insight into the mechanisms by which tau may be released and internalized by neurons and have started to provide insight into how tau pathology may spread in AD. In this review, we discuss the evidence for regulated tau release and its specific uptake by neurons. Furthermore, we identify possible therapeutic targets for preventing the propagation of tau pathology, as inhibition of tau transfer may restrict development of tau tangles in a small subset of neurons affected in early stages of AD and therefore prevent widespread neuron loss and cognitive dysfunction associated with later stages of the disease.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
United States 1 <1%
Australia 1 <1%
Unknown 162 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 45 27%
Researcher 30 18%
Student > Bachelor 28 17%
Student > Master 17 10%
Professor 7 4%
Other 20 12%
Unknown 19 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 37 22%
Neuroscience 35 21%
Biochemistry, Genetics and Molecular Biology 20 12%
Medicine and Dentistry 19 11%
Pharmacology, Toxicology and Pharmaceutical Science 9 5%
Other 21 13%
Unknown 25 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2015.
All research outputs
#5,231,148
of 17,351,915 outputs
Outputs from Alzheimer's Research & Therapy
#715
of 887 outputs
Outputs of similar age
#57,089
of 194,589 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#1
of 1 outputs
Altmetric has tracked 17,351,915 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 887 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.2. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,589 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them