Title |
Potential beneficial effects of ixmyelocel-T in the treatment of atherosclerotic diseases
|
---|---|
Published in |
Stem Cell Research & Therapy, November 2013
|
DOI | 10.1186/scrt346 |
Pubmed ID | |
Authors |
Kelly J Ledford, Nikki Murphy, Frank Zeigler, Ronnda L Bartel |
Abstract |
Advanced atherosclerotic lesions are characterized by lipid accumulation, inflammation, and defective efferocytosis. An ideal therapy should address all aspects of this multifactorial disease. Ixmyelocel-T therapy, an expanded autologous multicellular therapy showing clinical promise in the treatment of diseases associated with advanced atherosclerosis, includes a novel population of M2-like macrophages. Here, we examine the macrophages of ixmyelocel-T and determine their ability to influx modified cholesterol in an atheroprotective manner, maintaining cholesterol homeostasis and preventing cellular dysfunction and death, ultimately promoting reverse cholesterol efflux. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 9% |
Unknown | 10 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 27% |
Student > Doctoral Student | 1 | 9% |
Other | 1 | 9% |
Professor | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Other | 3 | 27% |
Unknown | 1 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 45% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 18% |
Nursing and Health Professions | 1 | 9% |
Engineering | 1 | 9% |
Unknown | 2 | 18% |