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Postnatal epigenetic reprogramming in the germline of a marsupial, the tammar wallaby

Overview of attention for article published in Epigenetics & Chromatin, June 2013
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Title
Postnatal epigenetic reprogramming in the germline of a marsupial, the tammar wallaby
Published in
Epigenetics & Chromatin, June 2013
DOI 10.1186/1756-8935-6-14
Pubmed ID
Authors

Shunsuke Suzuki, Geoffrey Shaw, Marilyn B Renfree

Abstract

Epigenetic reprogramming is essential to restore totipotency and to reset genomic imprints during mammalian germ cell development and gamete formation. The dynamic DNA methylation change at DMRs (differentially methylated regions) within imprinted domains and of retrotransposons is characteristic of this process. Both marsupials and eutherian mammals have genomic imprinting but these two subgroups have been evolving separately for up to 160 million years. Marsupials have a unique reproductive strategy and deliver tiny, altricial young that complete their development within their mother's pouch. Germ cell proliferation in the genital ridge continues after birth in the tammar wallaby (Macropus eugenii), and it is only after 25 days postpartum that female germ cells begin to enter meiosis and male germ cells begin to enter mitotic arrest. At least two marsupial imprinted loci (PEG10 and H19) also have DMRs. To investigate the evolution of epigenetic reprogramming in the marsupial germline, here we collected germ cells from male pouch young of the tammar wallaby and analysed the methylation status of PEG10 and H19 DMR, an LTR (long terminal repeat) and a non-LTR retrotransposons.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 26%
Student > Ph. D. Student 6 18%
Student > Master 5 15%
Professor > Associate Professor 3 9%
Student > Doctoral Student 2 6%
Other 5 15%
Unknown 4 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 35%
Biochemistry, Genetics and Molecular Biology 9 26%
Computer Science 4 12%
Medicine and Dentistry 2 6%
Unspecified 1 3%
Other 2 6%
Unknown 4 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2013.
All research outputs
#18,353,475
of 22,729,647 outputs
Outputs from Epigenetics & Chromatin
#492
of 564 outputs
Outputs of similar age
#146,603
of 195,542 outputs
Outputs of similar age from Epigenetics & Chromatin
#10
of 13 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 564 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,542 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.