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Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis

Overview of attention for article published in Critical Care, April 2017
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Title
Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis
Published in
Critical Care, April 2017
DOI 10.1186/s13054-017-1674-5
Pubmed ID
Authors

Ryan Haines, Siobhan Crichton, Jessica Wilson, David Treacher, Marlies Ostermann

Abstract

This study aimed to investigate whether cardiac troponin T (cTnT), cardiac troponin I (cTnI) and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with acute kidney injury (AKI) and need for acute renal replacement therapy (RRT) in adult patients admitted to the intensive care unit (ICU). We analysed prospectively collected data for patients admitted to the ICU between June and December 2010 for non-cardiac reasons. The Kidney Disease Improving Global Outcomes creatinine criteria were applied to identify patients with AKI including those who received acute RRT. Severity of illness was determined by the Acute Physiology and Chronic Health Evaluation (APACHE) II score and the Serial Organ Failure Assessment (SOFA) score. Regression analyses were performed to assess the association between cTnT, cTnI and NT-proBNP concentrations on the first day of ICU stay, maximum AKI stages and need for acute RRT. Sensitivity analysis was performed in which patients who developed a myocardial infarction during their stay in the ICU were excluded. Of 138 patients included, 73 (53%) had AKI and 40 (29%) required acute RRT. Patients with AKI were significantly older, more likely to have sepsis and had higher APACHE II and SOFA scores on admission to the ICU. In univariable analysis, cTnT, cTnI and NT-proBNP were significantly higher in those with AKI requiring acute RRT, but after adjustment for baseline differences in severity of illness, cumulative fluid balance and pre-existing comorbidities, only NT-proBNP remained significantly associated with worst stage of AKI and need for RRT. cTnT and cTnI were independently associated with the odds of any AKI but not with need for RRT. In a sensitivity analysis in which patients who had an acute myocardial infarction while in the ICU were excluded, NT-proBNP remained independently associated with AKI and acute RRT. In critically ill patients admitted to the ICU for non-cardiac reasons, admission NT-proBNP had the strongest independent association with maximum stage of AKI and need for RRT.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 15%
Other 7 15%
Student > Master 5 11%
Student > Doctoral Student 4 9%
Student > Bachelor 3 7%
Other 9 20%
Unknown 11 24%
Readers by discipline Count As %
Medicine and Dentistry 21 46%
Nursing and Health Professions 5 11%
Veterinary Science and Veterinary Medicine 2 4%
Psychology 2 4%
Agricultural and Biological Sciences 1 2%
Other 2 4%
Unknown 13 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2017.
All research outputs
#10,775,174
of 13,537,615 outputs
Outputs from Critical Care
#3,839
of 4,312 outputs
Outputs of similar age
#193,671
of 265,733 outputs
Outputs of similar age from Critical Care
#54
of 59 outputs
Altmetric has tracked 13,537,615 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,312 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.8. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,733 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.