↓ Skip to main content

Rubus occidentalis alleviates hyperalgesia induced by repeated intramuscular injection of acidic saline in rats

Overview of attention for article published in BMC Complementary and Alternative Medicine, July 2016
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
3 Dimensions

Readers on

mendeley
17 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Rubus occidentalis alleviates hyperalgesia induced by repeated intramuscular injection of acidic saline in rats
Published in
BMC Complementary and Alternative Medicine, July 2016
DOI 10.1186/s12906-016-1192-z
Pubmed ID
Authors

Geun Joo Choi, Hyun Kang, Won Joong Kim, Chong Wha Baek, Yong Hun Jung, Young Cheol Woo, Ji Wung Kwon

Abstract

The purpose of this study was to evaluate the antinociceptive effect of black raspberry (Rubus occidentalis) fruit extract (ROE) in a rat model of chronic muscle pain and examine the mechanisms involved. Adult male Sprague-Dawley rats were used, and chronic muscle pain was induced by two injections of acidic saline into one gastrocnemius muscle. For the first experiment, 50 rats were randomly assigned to five groups. After the development of hyperalgesia, rats were injected intraperitoneally with 0.9 % saline or ROE (10, 30, 100, or 300 mg/kg). For the second experiment, 70 rats were randomly assigned to seven groups. Rats were injected intraperitoneally with saline, yohimbine, dexmedetomidine, prazosin, atropine, mecamylamine, or naloxone after the development of hyperalgesia. Ten minutes later, ROE (300 mg/kg) was administered intraperitoneally. For both experiments, the mechanical withdrawal threshold (MWT) was evaluated with von Frey filaments before the first acidic saline injection, 24 h after the second injection, and at 15, 30, 45, 60, 80, 100, and 120 min, 24 and 48 h after the drug administration. Compared with the control group, the MWT significantly increased up to 45 min after injection of ROE 100 mg/kg and up to 60 min after injection of ROE 300 mg/kg, respectively. Injection of ROE together with yohimbine or mecamylamine significantly decreased the MWT compared with the effect of ROE alone, while ROE together with dexmedetomidine significantly increased the MWT. ROE showed antinociceptive activity against induced chronic muscle pain, which may be mediated by α2-adrenergic and nicotinic cholinergic receptors.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 29%
Student > Bachelor 3 18%
Other 2 12%
Student > Doctoral Student 1 6%
Lecturer 1 6%
Other 3 18%
Unknown 2 12%
Readers by discipline Count As %
Nursing and Health Professions 3 18%
Biochemistry, Genetics and Molecular Biology 2 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 12%
Medicine and Dentistry 2 12%
Agricultural and Biological Sciences 2 12%
Other 3 18%
Unknown 3 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2017.
All research outputs
#7,473,387
of 9,684,470 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,618
of 2,309 outputs
Outputs of similar age
#190,106
of 264,254 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#33
of 45 outputs
Altmetric has tracked 9,684,470 research outputs across all sources so far. This one is in the 12th percentile – i.e., 12% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,309 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,254 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.