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Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis

Overview of attention for article published in Arthritis Research & Therapy, November 2013
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Title
Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis
Published in
Arthritis Research & Therapy, November 2013
DOI 10.1186/ar4367
Pubmed ID
Authors

Wouter de Munter, Arjen B Blom, Monique M Helsen, Birgitte Walgreen, Peter M van der Kraan, Leo AB Joosten, Wim B van den Berg, Peter LEM van Lent

Abstract

Osteoarthritis (OA) is associated with the metabolic syndrome, however the underlying mechanisms remain unclear. We investigated whether low density lipoprotein (LDL) accumulation leads to increased LDL uptake by synovial macrophages and affects synovial activation, cartilage destruction and enthesophyte/osteophyte formation during experimental OA in mice.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 3%
Switzerland 1 2%
Unknown 58 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 20%
Student > Master 9 15%
Student > Ph. D. Student 8 13%
Student > Bachelor 7 11%
Student > Postgraduate 3 5%
Other 10 16%
Unknown 12 20%
Readers by discipline Count As %
Medicine and Dentistry 21 34%
Agricultural and Biological Sciences 8 13%
Biochemistry, Genetics and Molecular Biology 5 8%
Immunology and Microbiology 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 6 10%
Unknown 15 25%