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MG53′s new identity

Overview of attention for article published in Skeletal Muscle, November 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog

Citations

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11 Dimensions

Readers on

mendeley
37 Mendeley
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Title
MG53′s new identity
Published in
Skeletal Muscle, November 2013
DOI 10.1186/2044-5040-3-25
Pubmed ID
Authors

Jennifer R Levy, Kevin P Campbell, David J Glass

Abstract

Mitsugumin 53 (MG53) is a relatively newly identified tripartite motif-containing (TRIM) family muscle-specific E3 ubiquitin ligase that is expressed in skeletal muscle and the heart. It has been postulated to facilitate repair by targeting the site of an injury, and acting as a scaffold for assembly of a repair complex made up of dysferlin, annexin V, caveolin-3, and polymerase I and transcript release factor (PTRF). A recent letter published in Nature by Song et al. proposes an alternate function for MG53: as an E3 ligase that targets the insulin receptor and insulin receptor substrate 1 (IRS1) for degradation, therefore regulating muscle insulin signaling. This work is exciting, as it not only presents a novel role for MG53, but also suggests that muscle insulin signaling has a systemic influence on insulin resistance and the metabolic syndrome.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 30%
Researcher 4 11%
Student > Bachelor 4 11%
Professor > Associate Professor 4 11%
Student > Master 4 11%
Other 7 19%
Unknown 3 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 41%
Biochemistry, Genetics and Molecular Biology 10 27%
Medicine and Dentistry 4 11%
Unspecified 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 1 3%
Unknown 4 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2013.
All research outputs
#5,852,394
of 22,729,647 outputs
Outputs from Skeletal Muscle
#161
of 360 outputs
Outputs of similar age
#52,602
of 213,637 outputs
Outputs of similar age from Skeletal Muscle
#4
of 6 outputs
Altmetric has tracked 22,729,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 360 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,637 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.