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Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study

Overview of attention for article published in Radiation Oncology, November 2013
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Title
Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study
Published in
Radiation Oncology, November 2013
DOI 10.1186/1748-717x-8-262
Pubmed ID
Authors

Malene M Clausen, Anders E Hansen, Per Munck af Rosenschold, Andreas Kjær, Annemarie T Kristensen, Fintan J McEvoy, Svend A Engelholm

Abstract

Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between sub-volumes of FDG and hypoxia assessed by the uptake of 64Cu-ATSM in canine solid tumors, and evaluated the possibilities for dose redistribution within the gross tumor volume (GTV).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 30%
Student > Master 5 17%
Researcher 5 17%
Student > Doctoral Student 3 10%
Student > Bachelor 2 7%
Other 4 13%
Unknown 2 7%
Readers by discipline Count As %
Medicine and Dentistry 10 33%
Physics and Astronomy 8 27%
Veterinary Science and Veterinary Medicine 3 10%
Agricultural and Biological Sciences 2 7%
Nursing and Health Professions 1 3%
Other 2 7%
Unknown 4 13%