Title |
Activation of pro-oncogenic pathways in colorectal hyperplastic polyps
|
---|---|
Published in |
BMC Cancer, November 2013
|
DOI | 10.1186/1471-2407-13-531 |
Pubmed ID | |
Authors |
Catherine Do, Claudine Bertrand, Julien Palasse, Marie-Bernadette Delisle, Elizabeth Cohen-Jonathan-Moyal, Catherine Seva |
Abstract |
In contrast to sessile serrated adenomas and traditional serrated adenomas which are associated with a significant cancer risk, the role of hyperplastic polyps (HP) in colorectal carcinogenesis as well as the molecular mechanisms underlying their development remain controversial and still need to be clarified. Several reports suggest that a subset of HP may represent precursor lesions of some colorectal cancers. However, biomarkers are needed to identify the subset of HP that may have a malignant potential. The hormone precursor, progastrin (PG) has been involved in colon carcinogenesis and is known to activate pro-oncogenic pathways such as the ERK or the STAT3 pathway. We therefore analyzed PG expression and the activation of these signaling factors in HP. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 7% |
Unknown | 14 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 33% |
Student > Ph. D. Student | 4 | 27% |
Professor | 1 | 7% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 47% |
Agricultural and Biological Sciences | 3 | 20% |
Veterinary Science and Veterinary Medicine | 1 | 7% |
Unknown | 4 | 27% |