Title |
Towards an HIV cure: science and debate from the International AIDS Society 2013 symposium
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Published in |
Retrovirology, November 2013
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DOI | 10.1186/1742-4690-10-134 |
Pubmed ID | |
Authors |
Damian FJ Purcell, Julian H Elliott, Anna-Laura Ross, John Frater |
Abstract |
The International AIDS Society convened the multi-stakeholder "Towards an HIV Cure" symposium in Kuala Lumpur, Malaysia in 2013 to address the significant research challenges posed by the search for a cure for HIV infection. Current antiretroviral regimens select for a small reservoir of cells that harbour latent HIV provirus, produce few or no HIV virions, and resist detection or clearance by host immunity. The symposium examined basic molecular science and animal model data, and emerging and ongoing clinical trial results to prioritise strategies and determine the viral and immune responses that could lead to HIV remission without ART. Here we review the presentations that scrutinized the molecular mechanisms controlling virus expression from proviral DNA, and the intrinsic cellular restriction and immune mechanisms preventing viral production. Insights from the basic science have translated into new therapeutic strategies seeking HIV remission without ongoing therapy, and much interest was focused on these ongoing trials. We also summarise the emerging ethical issues and patient expectations as concepts move into the clinic. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 33% |
Germany | 1 | 11% |
Italy | 1 | 11% |
United Kingdom | 1 | 11% |
South Africa | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 56% |
Science communicators (journalists, bloggers, editors) | 3 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 8% |
Denmark | 1 | 4% |
Unknown | 22 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 32% |
Researcher | 5 | 20% |
Student > Master | 3 | 12% |
Other | 2 | 8% |
Professor | 1 | 4% |
Other | 2 | 8% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 40% |
Agricultural and Biological Sciences | 5 | 20% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Psychology | 1 | 4% |
Immunology and Microbiology | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 20% |