Title |
Spatial distribution of G6PD deficiency variants across malaria-endemic regions
|
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Published in |
Malaria Journal, November 2013
|
DOI | 10.1186/1475-2875-12-418 |
Pubmed ID | |
Authors |
Rosalind E Howes, Mewahyu Dewi, Frédéric B Piel, Wuelton M Monteiro, Katherine E Battle, Jane P Messina, Anavaj Sakuntabhai, Ari W Satyagraha, Thomas N Williams, J Kevin Baird, Simon I Hay |
Abstract |
Primaquine is essential for malaria control and elimination since it is the only available drug preventing multiple clinical attacks by relapses of Plasmodium vivax. It is also the only therapy against the sexual stages of Plasmodium falciparum infectious to mosquitoes, and is thus useful in preventing malaria transmission. However, the difficulties of diagnosing glucose-6-phosphate dehydrogenase deficiency (G6PDd) greatly hinder primaquine's widespread use, as this common genetic disorder makes patients susceptible to potentially severe and fatal primaquine-induced haemolysis. The risk of such an outcome varies widely among G6PD gene variants. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 1% |
Tanzania, United Republic of | 1 | <1% |
Portugal | 1 | <1% |
India | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 227 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 36 | 15% |
Student > Master | 32 | 14% |
Researcher | 31 | 13% |
Student > Ph. D. Student | 28 | 12% |
Other | 14 | 6% |
Other | 43 | 18% |
Unknown | 50 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 53 | 23% |
Biochemistry, Genetics and Molecular Biology | 42 | 18% |
Agricultural and Biological Sciences | 30 | 13% |
Immunology and Microbiology | 9 | 4% |
Nursing and Health Professions | 7 | 3% |
Other | 32 | 14% |
Unknown | 61 | 26% |