Title |
The Drosophila early ovarian transcriptome provides insight to the molecular causes of recombination rate variation across genomes
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Published in |
BMC Genomics, November 2013
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DOI | 10.1186/1471-2164-14-794 |
Pubmed ID | |
Authors |
Andrew B Adrian, Josep M Comeron |
Abstract |
Evidence in yeast indicates that gene expression is correlated with recombination activity and double-strand break (DSB) formation in some hotspots. Studies of nucleosome occupancy in yeast and mice also suggest that open chromatin influences the formation of DSBs. In Drosophila melanogaster, high-resolution recombination maps show an excess of DSBs within annotated transcripts relative to intergenic sequences. The impact of active transcription on recombination landscapes, however, remains unexplored in a multicellular organism. We then investigated the transcription profile during early meiosis in D. melanogaster females to obtain a glimpse at the relevant transcriptional dynamics during DSB formation, and test the specific hypothesis that DSBs preferentially target transcriptionally active genomic regions. |
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