Title |
Investigation of serum protein profiles in scrapie infected sheep by means of SELDI-TOF-MS and multivariate data analysis
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Published in |
BMC Research Notes, November 2013
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DOI | 10.1186/1756-0500-6-466 |
Pubmed ID | |
Authors |
Siv Meling, Olav M Kvalheim, Reidar Arneberg, Kjetil Bårdsen, Anne Hjelle, Martha J Ulvund |
Abstract |
Classical scrapie in sheep is a fatal neurodegenerative disease associated with the conversion PrPC to PrPSc. Much is known about genetic susceptibility, uptake and dissemination of PrPSc in the body, but many aspects of prion diseases are still unknown. Different proteomic techniques have been used during the last decade to investigate differences in protein profiles between affected animals and healthy controls. We have investigated the protein profiles in serum of sheep with scrapie and healthy controls by SELDI-TOF-MS and LC-MS/MS. Latent Variable methods such as Principal Component Analysis, Partial Least Squares-Discriminant Analysis and Target Projection methods were used to describe the MS data. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 5% |
Unknown | 18 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 42% |
Student > Bachelor | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Professor | 2 | 11% |
Student > Master | 2 | 11% |
Other | 2 | 11% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 32% |
Neuroscience | 4 | 21% |
Agricultural and Biological Sciences | 2 | 11% |
Engineering | 2 | 11% |
Computer Science | 2 | 11% |
Other | 1 | 5% |
Unknown | 2 | 11% |