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X Demographics
Mendeley readers
Attention Score in Context
| Title |
ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
|
|---|---|
| Published in |
Molecular Cancer, April 2017
|
| DOI | 10.1186/s12943-017-0648-1 |
| Pubmed ID | |
| Authors |
Yang Zhao, Xingbin Hu, Yajing Liu, Shumin Dong, Zhaowei Wen, Wanming He, Shuyi Zhang, Qiong Huang, Min Shi |
| Abstract |
Cancer cells are frequently confronted with metabolic stress in tumor microenvironments due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death through ROS-induced apoptosis. However, cancer cells can adapt to it by altering the metabolic pathways. AMPK and AKT are two primary effectors in response to metabolic stress: AMPK acts as an energy-sensing factor which rewires metabolism and maintains redox balance. AKT broadly promotes energy production in the nutrient abundance milieu, but the role of AKT under metabolic stress is in dispute. Recent studies show that AMPK and AKT display antagonistic roles under metabolic stress. Metabolic stress-induced ROS signaling lies in the hub between metabolic reprogramming and redox homeostasis. Here, we highlight the cross-talk between AMPK and AKT and their regulation on ROS production and elimination, which summarizes the mechanism of cancer cell adaptability under ROS stress and suggests potential options for cancer therapeutics. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 421 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 420 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 87 | 21% |
| Student > Master | 50 | 12% |
| Researcher | 48 | 11% |
| Student > Bachelor | 48 | 11% |
| Student > Doctoral Student | 23 | 5% |
| Other | 50 | 12% |
| Unknown | 115 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 127 | 30% |
| Agricultural and Biological Sciences | 59 | 14% |
| Medicine and Dentistry | 25 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 21 | 5% |
| Neuroscience | 13 | 3% |
| Other | 40 | 10% |
| Unknown | 136 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2023.
All research outputs
#15,010,169
of 24,273,038 outputs
Outputs from Molecular Cancer
#949
of 1,825 outputs
Outputs of similar age
#172,238
of 313,706 outputs
Outputs of similar age from Molecular Cancer
#13
of 33 outputs
Altmetric has tracked 24,273,038 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,825 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,706 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.