Title |
A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells
|
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Published in |
Arthritis Research & Therapy, November 2013
|
DOI | 10.1186/ar4379 |
Pubmed ID | |
Authors |
Akihiko Hiyama, Katsuya Yokoyama, Tadashi Nukaga, Daisuke Sakai, Joji Mochida |
Abstract |
Increased expression of the proinflammatory cytokine TNF-α in intervertebral discs (IVDs) leads to inflammation, which results in progressive IVD degeneration. We have previously reported that activation of Wnt-β-catenin (hereafter called Wnt) signaling suppresses the proliferation of nucleus pulposus cells and induces cell senescence, suggesting that Wnt signaling triggers the process of degeneration of the IVD. However, it is not known whether cross talk between TNF-α and Wnt signaling plays a role in the regulation of nucleus pulposus cells. The goal of the present study was to examine the effect of the interaction between Wnt signaling and the proinflammatory cytokine TNF-α in nucleus pulposus cells. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
Unknown | 64 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 27% |
Researcher | 9 | 14% |
Other | 6 | 9% |
Student > Bachelor | 6 | 9% |
Student > Master | 6 | 9% |
Other | 11 | 17% |
Unknown | 10 | 15% |
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Chemistry | 2 | 3% |
Other | 6 | 9% |
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