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A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells

Overview of attention for article published in Arthritis Research & Therapy, November 2013
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Title
A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells
Published in
Arthritis Research & Therapy, November 2013
DOI 10.1186/ar4379
Pubmed ID
Authors

Akihiko Hiyama, Katsuya Yokoyama, Tadashi Nukaga, Daisuke Sakai, Joji Mochida

Abstract

Increased expression of the proinflammatory cytokine TNF-α in intervertebral discs (IVDs) leads to inflammation, which results in progressive IVD degeneration. We have previously reported that activation of Wnt-β-catenin (hereafter called Wnt) signaling suppresses the proliferation of nucleus pulposus cells and induces cell senescence, suggesting that Wnt signaling triggers the process of degeneration of the IVD. However, it is not known whether cross talk between TNF-α and Wnt signaling plays a role in the regulation of nucleus pulposus cells. The goal of the present study was to examine the effect of the interaction between Wnt signaling and the proinflammatory cytokine TNF-α in nucleus pulposus cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 27%
Researcher 9 14%
Other 6 9%
Student > Bachelor 6 9%
Student > Master 6 9%
Other 11 17%
Unknown 10 15%
Readers by discipline Count As %
Medicine and Dentistry 13 20%
Biochemistry, Genetics and Molecular Biology 12 18%
Agricultural and Biological Sciences 12 18%
Engineering 7 11%
Chemistry 2 3%
Other 6 9%
Unknown 14 21%