Title |
STaRRRT: a table of short tandem repeats in regulatory regions of the human genome
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Published in |
BMC Genomics, November 2013
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DOI | 10.1186/1471-2164-14-795 |
Pubmed ID | |
Authors |
Katherine A Bolton, Jason P Ross, Desma M Grice, Nikola A Bowden, Elizabeth G Holliday, Kelly A Avery-Kiejda, Rodney J Scott |
Abstract |
Tandem repeats (TRs) are unstable regions commonly found within genomes that have consequences for evolution and disease. In humans, polymorphic TRs are known to cause neurodegenerative and neuromuscular disorders as well as being associated with complex diseases such as diabetes and cancer. If present in upstream regulatory regions, TRs can modify chromatin structure and affect transcription; resulting in altered gene expression and protein abundance. The most common TRs are short tandem repeats (STRs), or microsatellites. Promoter located STRs are considerably more polymorphic than coding region STRs. As such, they may be a common driver of phenotypic variation. To study STRs located in regulatory regions, we have performed genome-wide analysis to identify all STRs present in a region that is 2 kilobases upstream and 1 kilobase downstream of the transcription start sites of genes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 2% |
Unknown | 65 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 17 | 26% |
Student > Ph. D. Student | 11 | 17% |
Student > Bachelor | 5 | 8% |
Professor > Associate Professor | 5 | 8% |
Other | 4 | 6% |
Other | 14 | 21% |
Unknown | 10 | 15% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 24 | 36% |
Agricultural and Biological Sciences | 23 | 35% |
Medicine and Dentistry | 3 | 5% |
Computer Science | 2 | 3% |
Decision Sciences | 1 | 2% |
Other | 3 | 5% |
Unknown | 10 | 15% |