Title |
Duodenal mucosal risk markers in patients with familial adenomatous polyposis: effects of celecoxib/ursodeoxycholic acid co-treatment and comparison with patient controls
|
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Published in |
Orphanet Journal of Rare Diseases, November 2013
|
DOI | 10.1186/1750-1172-8-181 |
Pubmed ID | |
Authors |
Bjorn WH van Heumen, Hennie MJ Roelofs, René HM te Morsche, Fokko M Nagengast, Wilbert HM Peters |
Abstract |
Familial adenomatous polyposis (FAP) is a disease characterized by the development of hundreds to thousands of adenomatous polyps in the colorectum early in life. Virtually all patients with FAP will develop colorectal cancer before the age of 40 to 50 years, unless prophylactic colectomy is performed, which significantly improves their prognosis. The mortality pattern has changed and duodenal cancer now is one of the main cancer-related causes of death in these patients. Practically all patients with FAP develop premalignant duodenal adenomas, which may develop to duodenal cancer in approximately 3-7% of patients. Duodenal cancer in patients with FAP has a poor prognosis. The clinical challenge is to identify patients at high-risk for duodenal carcinoma. Chemoprevention would be desirable to avoid duodenectomy. The main goal of this study is to identify risk markers in normal duodenal mucosa of patients with FAP, that could help identify patients at increased risk for malignant transformation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Mexico | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 15% |
Student > Ph. D. Student | 4 | 12% |
Lecturer | 2 | 6% |
Student > Doctoral Student | 2 | 6% |
Librarian | 2 | 6% |
Other | 7 | 21% |
Unknown | 11 | 33% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 45% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Agricultural and Biological Sciences | 3 | 9% |
Social Sciences | 1 | 3% |
Unknown | 11 | 33% |