Title |
A novel cell nuclei segmentation method for 3D C. elegans embryonic time-lapse images
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Published in |
BMC Bioinformatics, November 2013
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DOI | 10.1186/1471-2105-14-328 |
Pubmed ID | |
Authors |
Long Chen, Leanne Lai Hang Chan, Zhongying Zhao, Hong Yan |
Abstract |
Recently a series of algorithms have been developed, providing automatic tools for tracing C. elegans embryonic cell lineage. In these algorithms, 3D images collected from a confocal laser scanning microscope were processed, the output of which is cell lineage with cell division history and cell positions with time. However, current image segmentation algorithms suffer from high error rate especially after 350-cell stage because of low signal-noise ratio as well as low resolution along the Z axis (0.5-1 microns). As a result, correction of the errors becomes a huge burden. These errors are mainly produced in the segmentation of nuclei. Thus development of a more accurate image segmentation algorithm will alleviate the hurdle for automated analysis of cell lineage. |
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