Title |
Development of a versatile enrichment analysis tool reveals associations between the maternal brain and mental health disorders, including autism
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Published in |
BMC Neuroscience, November 2013
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DOI | 10.1186/1471-2202-14-147 |
Pubmed ID | |
Authors |
Brian E Eisinger, Michael C Saul, Terri M Driessen, Stephen C Gammie |
Abstract |
A recent study of lateral septum (LS) suggested a large number of autism-related genes with altered expression in the postpartum state. However, formally testing the findings for enrichment of autism-associated genes proved to be problematic with existing software. Many gene-disease association databases have been curated which are not currently incorporated in popular, full-featured enrichment tools, and the use of custom gene lists in these programs can be difficult to perform and interpret. As a simple alternative, we have developed the Modular Single-set Enrichment Test (MSET), a minimal tool that enables one to easily evaluate expression data for enrichment of any conceivable gene list of interest. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 129 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 21 | 16% |
Student > Ph. D. Student | 17 | 13% |
Researcher | 16 | 12% |
Student > Bachelor | 13 | 10% |
Unspecified | 11 | 8% |
Other | 28 | 21% |
Unknown | 25 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 24 | 18% |
Medicine and Dentistry | 19 | 15% |
Unspecified | 11 | 8% |
Agricultural and Biological Sciences | 8 | 6% |
Biochemistry, Genetics and Molecular Biology | 8 | 6% |
Other | 31 | 24% |
Unknown | 30 | 23% |