Title |
Case–control study of HLA-G promoter methylation status, HPV infection and cervical neoplasia in Curitiba, Brazil: a pilot analysis
|
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Published in |
BMC Cancer, December 2012
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DOI | 10.1186/1471-2407-12-618 |
Pubmed ID | |
Authors |
Anna Gillio-Tos, Maria da Graça Bicalho, Valentina Fiano, Chiara Grasso, Valentina Tarallo, Laura De Marco, Morena Trevisan, MarinaBarbaradeSousa Xavier, Renata Slowik, Newton S Carvalho, Carlos A Maestri, Hadriano M Lacerda, Daniela Zugna, Lorenzo Richiardi, Franco Merletti |
Abstract |
The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The diminished capability of the immune system to control and resolve HPV infection is one of several hypotheses. The tolerogenic protein HLA-G has shown aberrant expression in a variety of cancers, which has been suggested as a mechanism for tumor escape from immunosurveillance. In the present study we evaluate the role of epigenetic modification (promoter de-methylation) of the HLA-G gene on susceptibility to HPV infection and development of high-grade cervical lesions. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 3 | 5% |
United Kingdom | 1 | 2% |
Unknown | 61 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 20% |
Student > Ph. D. Student | 10 | 15% |
Researcher | 7 | 11% |
Student > Bachelor | 4 | 6% |
Other | 3 | 5% |
Other | 7 | 11% |
Unknown | 21 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 29% |
Agricultural and Biological Sciences | 10 | 15% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Immunology and Microbiology | 3 | 5% |
Arts and Humanities | 2 | 3% |
Other | 7 | 11% |
Unknown | 19 | 29% |