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Case–control study of HLA-G promoter methylation status, HPV infection and cervical neoplasia in Curitiba, Brazil: a pilot analysis

Overview of attention for article published in BMC Cancer, December 2012
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Title
Case–control study of HLA-G promoter methylation status, HPV infection and cervical neoplasia in Curitiba, Brazil: a pilot analysis
Published in
BMC Cancer, December 2012
DOI 10.1186/1471-2407-12-618
Pubmed ID
Authors

Anna Gillio-Tos, Maria da Graça Bicalho, Valentina Fiano, Chiara Grasso, Valentina Tarallo, Laura De Marco, Morena Trevisan, MarinaBarbaradeSousa Xavier, Renata Slowik, Newton S Carvalho, Carlos A Maestri, Hadriano M Lacerda, Daniela Zugna, Lorenzo Richiardi, Franco Merletti

Abstract

The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The diminished capability of the immune system to control and resolve HPV infection is one of several hypotheses. The tolerogenic protein HLA-G has shown aberrant expression in a variety of cancers, which has been suggested as a mechanism for tumor escape from immunosurveillance. In the present study we evaluate the role of epigenetic modification (promoter de-methylation) of the HLA-G gene on susceptibility to HPV infection and development of high-grade cervical lesions.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 3 5%
United Kingdom 1 2%
Unknown 61 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 20%
Student > Ph. D. Student 10 15%
Researcher 7 11%
Student > Bachelor 4 6%
Other 3 5%
Other 7 11%
Unknown 21 32%
Readers by discipline Count As %
Medicine and Dentistry 19 29%
Agricultural and Biological Sciences 10 15%
Biochemistry, Genetics and Molecular Biology 5 8%
Immunology and Microbiology 3 5%
Arts and Humanities 2 3%
Other 7 11%
Unknown 19 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2013.
All research outputs
#20,210,424
of 22,731,677 outputs
Outputs from BMC Cancer
#6,489
of 8,270 outputs
Outputs of similar age
#248,925
of 280,767 outputs
Outputs of similar age from BMC Cancer
#109
of 118 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,270 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,767 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 118 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.