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Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein

Overview of attention for article published in Acta Neuropathologica Communications, June 2013
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Title
Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein
Published in
Acta Neuropathologica Communications, June 2013
DOI 10.1186/2051-5960-1-25
Pubmed ID
Authors

Alejandra Rangel, Brent Race, Mikael Klingeborn, James Striebel, Bruce Chesebro

Abstract

In some prion diseases, misfolded aggregated protease-resistant prion protein (PrPres) is found in brain as amyloid, which can cause cerebral amyloid angiopathy. Small diffusible precursors of PrPres amyloid might flow with brain interstitial fluid (ISF), possibly accounting for the perivascular and intravascular distribution of PrPres amyloid. We previously reported that PrPres amyloid in scrapie-infected transgenic mice appeared to delay clearance of microinjected brain ISF tracer molecules.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 29%
Professor 2 12%
Student > Doctoral Student 2 12%
Researcher 2 12%
Professor > Associate Professor 2 12%
Other 0 0%
Unknown 4 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 29%
Agricultural and Biological Sciences 3 18%
Neuroscience 2 12%
Immunology and Microbiology 2 12%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Other 0 0%
Unknown 4 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2013.
All research outputs
#18,354,532
of 22,731,677 outputs
Outputs from Acta Neuropathologica Communications
#1,226
of 1,368 outputs
Outputs of similar age
#147,842
of 196,857 outputs
Outputs of similar age from Acta Neuropathologica Communications
#25
of 40 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,368 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.7. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,857 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.