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ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) does not affect proliferation, apoptosis, or angiogenesis as compared to standard liver resection for colorectal…

Overview of attention for article published in World Journal of Surgical Oncology, March 2017
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Title
ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) does not affect proliferation, apoptosis, or angiogenesis as compared to standard liver resection for colorectal liver metastases
Published in
World Journal of Surgical Oncology, March 2017
DOI 10.1186/s12957-017-1121-8
Pubmed ID
Authors

Katharina Joechle, Christian Moser, Petra Ruemmele, Katharina M. Schmidt, Jens M. Werner, Edward K. Geissler, Hans J. Schlitt, Sven A. Lang

Abstract

ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a novel two-stage strategy to induce rapid hypertrophy of the future liver remnant (FLR) when patients are in danger of postoperative liver failure due to insufficient FLR. However, the effects of ALPPS on colorectal liver metastases (CRLM) are not clear so far. The aim of our study was to determine whether ALPPS induces proliferation, apoptosis, or vascularization compared to standard (one-stage) liver resection. Six patients who underwent ALPPS were matched with 12 patients undergoing standard liver resection regarding characteristics of the metastases (size, number), time of appearance (syn-/metachronous), preoperative chemotherapy, primary tumor (localization, TNM stage, grading), and patient variables (gender, age). The largest resected metastasis was used for the analyses. Tissue was stained for tumor cell proliferation (Ki67), apoptosis (TUNEL, caspase-3), vascularization (CD31), and pericytes (αSMA). Vascularization (CD31; p = 0.149), proliferation (Mib-1; p = 0.244), and αSMA expression (p = 0.205) did not significantly differ between the two groups, although a trend towards less proliferation and αSMA expression was observed in patients undergoing ALPPS. Concerning apoptosis, caspase-3 staining showed significantly fewer apoptotic cells upon ALPPS (p < 0.0001), but this was not confirmed by TUNEL staining (p = 0.7344). ALPPS does not induce proliferation, apoptosis, or vascularization of CRLM when compared to standard liver resection.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 19%
Student > Postgraduate 4 15%
Student > Doctoral Student 3 11%
Researcher 3 11%
Student > Bachelor 2 7%
Other 2 7%
Unknown 8 30%
Readers by discipline Count As %
Medicine and Dentistry 14 52%
Materials Science 1 4%
Agricultural and Biological Sciences 1 4%
Unknown 11 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2017.
All research outputs
#20,414,746
of 22,965,074 outputs
Outputs from World Journal of Surgical Oncology
#1,588
of 2,052 outputs
Outputs of similar age
#268,332
of 307,962 outputs
Outputs of similar age from World Journal of Surgical Oncology
#8
of 15 outputs
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So far Altmetric has tracked 2,052 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.