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Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein

Overview of attention for article published in Acta Neuropathologica Communications, November 2013
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Title
Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein
Published in
Acta Neuropathologica Communications, November 2013
DOI 10.1186/2051-5960-1-74
Pubmed ID
Authors

Atsushi Kobayashi, Yasushi Iwasaki, Hiroyuki Otsuka, Masahito Yamada, Mari Yoshida, Yuichi Matsuura, Shirou Mohri, Tetsuyuki Kitamoto

Abstract

Sporadic Creutzfeldt-Jakob disease is classified according to the genotype at polymorphic codon 129 (M or V) of the prion protein (PrP) gene and the type (1 or 2) of abnormal isoform of PrP (PrPSc) in the brain. The most complicated entity in the current classification system is MV2, since it shows wide phenotypic variations, i.e., MV2 cortical form (MV2C), MV2 with kuru plaques (MV2K), or a mixed form (MV2K + C). To resolve their complicated pathogenesis, we performed a comprehensive analysis of the three MV2 subgroups based on histopathological, molecular, and transmission properties.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 23%
Student > Ph. D. Student 4 18%
Student > Bachelor 2 9%
Professor 2 9%
Student > Master 2 9%
Other 4 18%
Unknown 3 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 23%
Agricultural and Biological Sciences 4 18%
Medicine and Dentistry 4 18%
Neuroscience 3 14%
Immunology and Microbiology 1 5%
Other 2 9%
Unknown 3 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2013.
All research outputs
#20,210,424
of 22,731,677 outputs
Outputs from Acta Neuropathologica Communications
#1,298
of 1,368 outputs
Outputs of similar age
#184,994
of 212,395 outputs
Outputs of similar age from Acta Neuropathologica Communications
#14
of 14 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,368 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,395 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.