Title |
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
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Published in |
BMC Medicine, June 2008
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DOI | 10.1186/1741-7015-6-14 |
Pubmed ID | |
Authors |
Joachim Silber, Daniel A Lim, Claudia Petritsch, Anders I Persson, Alika K Maunakea, Mamie Yu, Scott R Vandenberg, David G Ginzinger, C David James, Joseph F Costello, Gabriele Bergers, William A Weiss, Arturo Alvarez-Buylla, J Graeme Hodgson |
Abstract |
Glioblastoma multiforme (GBM) is an invariably fatal central nervous system tumor despite treatment with surgery, radiation, and chemotherapy. Further insights into the molecular and cellular mechanisms that drive GBM formation are required to improve patient outcome. MicroRNAs are emerging as important regulators of cellular differentiation and proliferation, and have been implicated in the etiology of a variety of cancers, yet the role of microRNAs in GBM remains poorly understood. In this study, we investigated the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 10 | 2% |
Brazil | 3 | <1% |
Germany | 2 | <1% |
Denmark | 2 | <1% |
Belgium | 2 | <1% |
Australia | 1 | <1% |
Hong Kong | 1 | <1% |
Italy | 1 | <1% |
France | 1 | <1% |
Other | 7 | 2% |
Unknown | 403 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 93 | 21% |
Researcher | 90 | 21% |
Student > Master | 53 | 12% |
Student > Bachelor | 51 | 12% |
Student > Doctoral Student | 23 | 5% |
Other | 79 | 18% |
Unknown | 44 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 145 | 33% |
Medicine and Dentistry | 90 | 21% |
Biochemistry, Genetics and Molecular Biology | 71 | 16% |
Neuroscience | 40 | 9% |
Engineering | 6 | 1% |
Other | 31 | 7% |
Unknown | 50 | 12% |