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Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells

Overview of attention for article published in BMC Molecular and Cell Biology, November 2013
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Citations

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Title
Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells
Published in
BMC Molecular and Cell Biology, November 2013
DOI 10.1186/1471-2091-14-34
Pubmed ID
Authors

Luisa Massai, Lara Petricca, Letizia Magnoni, Luca Rovetini, Salman Haider, Ralph Andre, Sarah J Tabrizi, Sigurd D Süssmuth, Bernhard G Landwehrmeyer, Andrea Caricasole, Giuseppe Pollio, Simonetta Bernocco

Abstract

Huntington's disease (HD) is a monogenic disorder caused by an aberrant expansion of CAG repeats in the huntingtin gene (HTT). Pathogenesis is associated with expression of the mutant (mHTT) protein in the CNS, with its levels most likely related to disease progression and symptom severity. Since non-invasive methods to quantify HTT in the CNS do not exist, measuring amount of soluble HTT in peripheral cells represents an important step in development of disease-modifying interventions in HD.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Brazil 1 3%
Unknown 36 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 32%
Researcher 6 16%
Student > Master 5 13%
Student > Bachelor 4 11%
Student > Doctoral Student 2 5%
Other 4 11%
Unknown 5 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 29%
Biochemistry, Genetics and Molecular Biology 5 13%
Neuroscience 4 11%
Medicine and Dentistry 4 11%
Immunology and Microbiology 2 5%
Other 7 18%
Unknown 5 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2013.
All research outputs
#20,653,708
of 25,371,288 outputs
Outputs from BMC Molecular and Cell Biology
#935
of 1,232 outputs
Outputs of similar age
#243,114
of 317,646 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#21
of 28 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,232 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,646 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.