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Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models

Overview of attention for article published in Journal of Ovarian Research, November 2013
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Title
Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models
Published in
Journal of Ovarian Research, November 2013
DOI 10.1186/1757-2215-6-78
Pubmed ID
Authors

Zaynab Al-Eisawi, Philip Beale, Charles Chan, Jun Q Yu, Fazlul Huq

Abstract

Ovarian cancer remains an on-going challenge mainly due to the development of drug resistance and also because the cancer is likely to have metastasized at the time of diagnosis. Currently, chemotherapy based on platinum drugs such as cisplatin is the primary treatment for the disease. Copper transporter 1 is involved in the transport of cisplatin into the cell, but is also down-regulated by the drug. Bortezomib, a proteasome inhibitor, has been reported to block this platinum-induced down-regulation of CTR1, so that in the presence of bortezomib, the cellular uptake of platinum drugs may be increased. Increased platinum accumulation may result in increased platinum - DNA binding so that the platinum drug in combination with bortezomib may produce enhanced cell kill.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 6%
Luxembourg 1 6%
Unknown 14 88%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 3 19%
Researcher 3 19%
Student > Ph. D. Student 3 19%
Unspecified 1 6%
Student > Doctoral Student 1 6%
Other 2 13%
Unknown 3 19%
Readers by discipline Count As %
Chemistry 4 25%
Agricultural and Biological Sciences 3 19%
Medicine and Dentistry 2 13%
Unspecified 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 1 6%
Unknown 4 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2013.
All research outputs
#20,211,690
of 22,733,113 outputs
Outputs from Journal of Ovarian Research
#425
of 582 outputs
Outputs of similar age
#187,318
of 215,020 outputs
Outputs of similar age from Journal of Ovarian Research
#5
of 7 outputs
Altmetric has tracked 22,733,113 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 582 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,020 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.