Title |
Association of candidate single nucleotide polymorphisms with somatic mutation of the epidermal growth factor receptor pathway
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Published in |
BMC Medical Genomics, October 2013
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DOI | 10.1186/1755-8794-6-43 |
Pubmed ID | |
Authors |
Samuel Wormald, Liz Milla, Liam O’Connor |
Abstract |
Tumour growth in colorectal cancer and other solid cancers is frequently supported by activating mutations in the epidermal growth factor receptor (EGFR) signaling pathway (Patholog Res Int 2011:932932, 2011). Treatment of metastatic colorectal cancer with targeted anti-EGFR therapeutics such as cetuximab extends survival in only 25% of patients who test wild-type for KRAS, while the majority of patients prove resistant (J Clin Oncol 28(7):1254-1261, 2010).Prediction of cetuximab responsiveness for KRAS wild-type colorectal cancers is currently not well defined, and prognostic biomarkers would help tailor treatment to individual patients. Somatic mutation of the EGFR signalling pathway is a prevalent mechanism of resistance to cetuximab (Nature 486(7404):532-536, 2012). If the human genome harbours variants that influence susceptibility of the EGFR pathway to oncogenic mutation, such variants could also be prognostic for cetuximab responsiveness. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Ecuador | 1 | 3% |
Unknown | 30 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 22% |
Researcher | 5 | 16% |
Student > Master | 5 | 16% |
Other | 4 | 13% |
Student > Postgraduate | 4 | 13% |
Other | 3 | 9% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 28% |
Biochemistry, Genetics and Molecular Biology | 8 | 25% |
Agricultural and Biological Sciences | 6 | 19% |
Computer Science | 2 | 6% |
Physics and Astronomy | 1 | 3% |
Other | 1 | 3% |
Unknown | 5 | 16% |