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X Demographics
Mendeley readers
Attention Score in Context
| Title |
An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models
|
|---|---|
| Published in |
Breast Cancer Research, September 2013
|
| DOI | 10.1186/bcr3480 |
| Pubmed ID | |
| Authors |
Wenle Xia, Emanual F Petricoin, Sumin Zhao, Leihua Liu, Takuya Osada, Qing Cheng, Julia D Wulfkuhle, William R Gwin, Xiaoyi Yang, Rosa I Gallagher, Sarah Bacus, H Kim Lyerly, Neil L Spector |
| Abstract |
The human epidermal growth factor receptor 2 (HER2) receptor tyrosine kinase (RTK) oncogene is an attractive therapeutic target for the treatment of HER2-addicted tumors. Although lapatinib, an FDA-approved small-molecule HER2 and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), represents a significant therapeutic advancement in the treatment of HER2+ breast cancers, responses to lapatinib have not been durable. Consequently, elucidation of mechanisms of acquired therapeutic resistance to HER-directed therapies is of critical importance. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| United Kingdom | 1 | <1% |
| Unknown | 214 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 61 | 28% |
| Student > Ph. D. Student | 22 | 10% |
| Researcher | 22 | 10% |
| Student > Master | 9 | 4% |
| Student > Doctoral Student | 5 | 2% |
| Other | 10 | 5% |
| Unknown | 89 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 41 | 19% |
| Biochemistry, Genetics and Molecular Biology | 33 | 15% |
| Agricultural and Biological Sciences | 28 | 13% |
| Medicine and Dentistry | 15 | 7% |
| Chemistry | 3 | 1% |
| Other | 6 | 3% |
| Unknown | 92 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2023.
All research outputs
#5,240,751
of 25,374,917 outputs
Outputs from Breast Cancer Research
#616
of 2,053 outputs
Outputs of similar age
#43,810
of 213,374 outputs
Outputs of similar age from Breast Cancer Research
#12
of 33 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 213,374 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.