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Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood–brain barrier model

Overview of attention for article published in Alzheimer's Research & Therapy, November 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
93 Mendeley
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Title
Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood–brain barrier model
Published in
Alzheimer's Research & Therapy, November 2013
DOI 10.1186/alzrt225
Pubmed ID
Authors

Sabrina Meister, Iavor Zlatev, Julia Stab, Dominic Docter, Sandra Baches, Roland H Stauber, Mordechai Deutsch, Reinhold Schmidt, Stefan Ropele, Manfred Windisch, Klaus Langer, Sylvia Wagner, Hagen von Briesen, Sascha Weggen, Claus U Pietrzik

Abstract

The amyloid-β42 (Aβ42) peptide plays a crucial role in the pathogenesis of Alzheimer's disease (AD), the most common neurodegenerative disorder affecting the elderly. Over the past years, several approaches and compounds developed for the treatment of AD have failed in clinical studies, likely in part due to their low penetration of the blood-brain barrier (BBB). Since nanotechnology-based strategies offer new possibilities for the delivery of drugs to the brain, this technique is studied intensively for the treatment of AD and other neurological disorders.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Spain 1 1%
Poland 1 1%
Germany 1 1%
Unknown 89 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 18%
Student > Master 17 18%
Researcher 13 14%
Student > Bachelor 10 11%
Student > Doctoral Student 8 9%
Other 15 16%
Unknown 13 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 24%
Pharmacology, Toxicology and Pharmaceutical Science 11 12%
Medicine and Dentistry 9 10%
Engineering 7 8%
Biochemistry, Genetics and Molecular Biology 6 6%
Other 18 19%
Unknown 20 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2013.
All research outputs
#4,835,823
of 25,373,627 outputs
Outputs from Alzheimer's Research & Therapy
#1,056
of 1,464 outputs
Outputs of similar age
#52,688
of 319,987 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#7
of 19 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,464 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,987 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.