Title |
Transcriptomics to study the effect of a Mediterranean-inspired diet on inflammation in Crohn's disease patients
|
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Published in |
Human Genomics, November 2013
|
DOI | 10.1186/1479-7364-7-24 |
Pubmed ID | |
Authors |
Gareth Marlow, Stephanie Ellett, Isobel R Ferguson, Shuotun Zhu, Nishi Karunasinghe, Amalini C Jesuthasan, Dug Yeo Han, Alan G Fraser, Lynnette R Ferguson |
Abstract |
Inflammation is an essential immune response; however, chronic inflammation results in disease including Crohn's disease. Therefore, reducing the inflammation can yield a significant health benefit, and one way to achieve this is through diet. We developed a Mediterranean-inspired anti-inflammatory diet and used this diet in a 6-week intervention in a Crohn's disease population. We examined changes in inflammation and also in the gut microbiota. We compared the results of established biomarkers, C-reactive protein and the micronuclei assay, of inflammation with results from a transcriptomic approach. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 9 | 47% |
United States | 1 | 5% |
Mexico | 1 | 5% |
United Kingdom | 1 | 5% |
Unknown | 7 | 37% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 13 | 68% |
Practitioners (doctors, other healthcare professionals) | 4 | 21% |
Scientists | 2 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Norway | 1 | <1% |
South Africa | 1 | <1% |
New Zealand | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 245 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 41 | 16% |
Student > Bachelor | 32 | 13% |
Researcher | 26 | 10% |
Student > Ph. D. Student | 23 | 9% |
Student > Postgraduate | 21 | 8% |
Other | 44 | 18% |
Unknown | 63 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 52 | 21% |
Agricultural and Biological Sciences | 31 | 12% |
Nursing and Health Professions | 30 | 12% |
Biochemistry, Genetics and Molecular Biology | 27 | 11% |
Immunology and Microbiology | 6 | 2% |
Other | 34 | 14% |
Unknown | 70 | 28% |