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Global analysis of protein lysine succinylation profiles in common wheat

Overview of attention for article published in BMC Genomics, April 2017
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Title
Global analysis of protein lysine succinylation profiles in common wheat
Published in
BMC Genomics, April 2017
DOI 10.1186/s12864-017-3698-2
Pubmed ID
Authors

Yumei Zhang, Guangyuan Wang, Limin Song, Ping Mu, Shu Wang, Wenxing Liang, Qi Lin

Abstract

Protein lysine succinylation is an important post-translational modification and plays a critical regulatory role in almost every aspects of cell metabolism in both eukaryotes and prokaryotes. Common wheat is one of the major global cereal crops. However, to date, little is known about the functions of lysine succinylation in this plant. Here, we performed a global analysis of lysine succinylation in wheat and examined its overlap with lysine acetylation. In total, 330 lysine succinylated modification sites were identified in 173 proteins. Bioinformatics analysis showed that the modified proteins are distributed in multiple subcellular compartments and are involved in a wide variety of biological processes such as photosynthesis and the Calvin-Benson cycle, suggesting an important role for lysine succinylation in these processes. Five putative succinylation motifs were identified. A protein interaction network analysis revealed that diverse interactions are modulated by protein succinylation. Moreover, 21 succinyl-lysine sites were found to be acetylated at the same position, and 33 proteins were modified by both acetylation and succinylation, suggesting an extensive overlap between succinylation and acetylation in common wheat. Comparative analysis indicated that lysine succinylation is conserved between common wheat and Brachypodium distachyon. These results suggest that lysine succinylation is involved in diverse biological processes, especially in photosynthesis and carbon fixation. This systematic analysis represents the first global analysis of lysine succinylation in common wheat and provides an important resource for exploring the physiological role of lysine succinylation in this cereal crop and likely in all plants.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 15%
Student > Master 3 12%
Student > Ph. D. Student 3 12%
Student > Doctoral Student 2 8%
Professor 2 8%
Other 2 8%
Unknown 10 38%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 35%
Biochemistry, Genetics and Molecular Biology 4 15%
Immunology and Microbiology 1 4%
Unknown 12 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2017.
All research outputs
#18,542,806
of 22,965,074 outputs
Outputs from BMC Genomics
#8,217
of 10,686 outputs
Outputs of similar age
#235,617
of 310,204 outputs
Outputs of similar age from BMC Genomics
#161
of 203 outputs
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We're also able to compare this research output to 203 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.