Title |
Leukemia cells induce changes in human bone marrow stromal cells
|
---|---|
Published in |
Journal of Translational Medicine, December 2013
|
DOI | 10.1186/1479-5876-11-298 |
Pubmed ID | |
Authors |
Sara Civini, Ping Jin, Jiaqiang Ren, Marianna Sabatino, Luciano Castiello, Jianjian Jin, Huan Wang, Yuanlong Zhao, Francesco Marincola, David Stroncek |
Abstract |
Bone marrow stromal cells (BMSCs) are multipotent cells that support angiogenesis, wound healing, and immunomodulation. In the hematopoietic niche, they nurture hematopoietic cells, leukemia, tumors and metastasis. BMSCs secrete of a wide range of cytokines, growth factors and matrix proteins which contribute to the pro-tumorigenic marrow microenvironment. The inflammatory cytokines IFN-γ and TNF-α change the BMSC secretome and we hypothesized that factors produced by tumors or leukemia would also affect the BMSC secretome and investigated the interaction of leukemia cells with BMSCs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Russia | 1 | 20% |
Spain | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | <1% |
Turkey | 1 | <1% |
India | 1 | <1% |
Unknown | 110 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 34 | 30% |
Researcher | 18 | 16% |
Student > Master | 17 | 15% |
Student > Bachelor | 12 | 11% |
Student > Doctoral Student | 5 | 4% |
Other | 14 | 12% |
Unknown | 13 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 35 | 31% |
Agricultural and Biological Sciences | 32 | 28% |
Medicine and Dentistry | 18 | 16% |
Engineering | 4 | 4% |
Nursing and Health Professions | 2 | 2% |
Other | 4 | 4% |
Unknown | 18 | 16% |