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On the amyloid datasets used for training PAFIG ­ how (not) to extend the experimental dataset of hexapeptides

Overview of attention for article published in BMC Bioinformatics, December 2013
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Title
On the amyloid datasets used for training PAFIG ­ how (not) to extend the experimental dataset of hexapeptides
Published in
BMC Bioinformatics, December 2013
DOI 10.1186/1471-2105-14-351
Pubmed ID
Authors

Malgorzata Kotulska, Olgierd Unold

Abstract

Amyloids are proteins capable of forming aberrant intramolecular contact sites, characteristic of beta zipper configuration. Amyloids can underlie serious health conditions, e.g. Alzheimer's or Parkinson's diseases. It has been proposed that short segments of amino acids can be responsible for protein amyloidogenicity, but no more than two hundred such hexapeptides have been experimentally found. The authors of the computational tool Pafig published in BMC Bioinformatics a method for extending the amyloid hexapeptide dataset that could be used for training and testing models. They assumed that all hexapeptides belonging to an amyloid protein can be regarded as amylopositive, while those from proteins never reported as amyloid are always amylonegative. Here we show why the above described method of extending datasets is wrong and discuss the reasons why the incorrect data could lead to falsely correct classification.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 29%
Student > Ph. D. Student 4 17%
Professor > Associate Professor 3 13%
Student > Bachelor 2 8%
Student > Postgraduate 2 8%
Other 5 21%
Unknown 1 4%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 25%
Medicine and Dentistry 5 21%
Computer Science 4 17%
Agricultural and Biological Sciences 2 8%
Engineering 2 8%
Other 4 17%
Unknown 1 4%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2013.
All research outputs
#20,211,690
of 22,733,113 outputs
Outputs from BMC Bioinformatics
#6,838
of 7,266 outputs
Outputs of similar age
#267,247
of 306,889 outputs
Outputs of similar age from BMC Bioinformatics
#99
of 107 outputs
Altmetric has tracked 22,733,113 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,266 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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