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Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy

Overview of attention for article published in Acta Neuropathologica Communications, July 2013
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Title
Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy
Published in
Acta Neuropathologica Communications, July 2013
DOI 10.1186/2051-5960-1-39
Pubmed ID
Authors

Pan Pan, Rick T Dobrowsky

Abstract

Aberrant neuron/glia interactions can contribute to a variety of neurodegenerative diseases and we have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth factor receptor (EGFR) family, can contribute to the development of diabetic peripheral neuropathy (DPN). In peripheral nerves, Erb B receptors are activated by various members of the neuregulin-1 (NRG1) family including NRG1 Type I, NRG1 Type II and NRG1 Type III to regulate Schwann cell (SC) growth, migration, differentiation and dedifferentiation. Alternatively, Erb B2 activity can be negatively regulated by association with the Erb B2-interacting protein, erbin. Since the effect of diabetes on the expression of NRG1 isoforms and erbin in peripheral nerve are unknown, the current study determined whether changes in NRG1 isoforms and erbin may be associated with altered Erb B2 signaling in DPN.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 22%
Student > Ph. D. Student 6 19%
Researcher 4 13%
Lecturer 2 6%
Student > Postgraduate 2 6%
Other 4 13%
Unknown 7 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 19%
Agricultural and Biological Sciences 6 19%
Medicine and Dentistry 5 16%
Neuroscience 3 9%
Nursing and Health Professions 2 6%
Other 1 3%
Unknown 9 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2013.
All research outputs
#18,355,685
of 22,733,113 outputs
Outputs from Acta Neuropathologica Communications
#1,226
of 1,368 outputs
Outputs of similar age
#128,847
of 172,150 outputs
Outputs of similar age from Acta Neuropathologica Communications
#15
of 25 outputs
Altmetric has tracked 22,733,113 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,368 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.7. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.