Title |
Multicolor banding remains an important adjunct to array CGH and conventional karyotyping
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Published in |
Molecular Cytogenetics, December 2013
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DOI | 10.1186/1755-8166-6-55 |
Pubmed ID | |
Authors |
Susan M Bint, Angela F Davies, Caroline Mackie Ogilvie |
Abstract |
Array comparative genomic hybridization (CGH) for high resolution detection of chromosome imbalance, and karyotype analysis using G-banded chromosomes for detection of chromosome rearrangements, provide a powerful diagnostic armoury for clinical cytogenetics. However, abnormalities detected by karyotype analysis cannot always be characterised by scrutinising the G-banded pattern alone, and imbalance detected by array CGH cannot always be visualised in the context of metaphase chromosomes. In some cases further techniques are needed for detailed characterisation of chromosomal abnormalities. We investigated seven cases involving structural chromosome rearrangements detected by karyotype analysis, and one case where imbalance was primarily detected by array CGH. Multicolor banding (MCB) was used in all cases and proved invaluable in understanding the detailed structure of the abnormalities. |
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