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The cyclophilins

Overview of attention for article published in Genome Biology, June 2005
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
2 news outlets
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
553 Dimensions

Readers on

mendeley
406 Mendeley
citeulike
4 CiteULike
connotea
2 Connotea
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Title
The cyclophilins
Published in
Genome Biology, June 2005
DOI 10.1186/gb-2005-6-7-226
Pubmed ID
Authors

Ping Wang, Joseph Heitman

Abstract

Cyclophilins (Enzyme Commission (EC) number 5.1.2.8) belong to a group of proteins that have peptidyl-prolyl cis-trans isomerase activity; such proteins are collectively known as immunophilins and also include the FK-506-binding proteins and the parvulins. Cyclophilins are found in all cells of all organisms studied, in both prokaryotes and eukaryotes; humans have a total of 16 cyclophilin proteins, Arabidopsis up to 29 and Saccharomyces 8. The first member of the cyclophilins to be identified in mammals, cyclophilin A, is the major cellular target for, and thus mediates the actions of, the immunosuppressive drug cyclosporin A. Cyclophilin A forms a ternary complex with cyclosporin A and the calcium-calmodulin-activated serine/threonine-specific protein phosphatase calcineurin; formation of this complex prevents calcineurin from regulating cytokine gene transcription. Recent studies have implicated a diverse array of additional cellular functions for cyclophilins, including roles as chaperones and in cell signaling.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 406 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 1%
United Kingdom 3 <1%
Malaysia 1 <1%
France 1 <1%
Portugal 1 <1%
Slovakia 1 <1%
Canada 1 <1%
Brazil 1 <1%
Nigeria 1 <1%
Other 3 <1%
Unknown 388 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 89 22%
Researcher 73 18%
Student > Master 51 13%
Student > Bachelor 46 11%
Student > Doctoral Student 20 5%
Other 57 14%
Unknown 70 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 135 33%
Biochemistry, Genetics and Molecular Biology 86 21%
Medicine and Dentistry 32 8%
Chemistry 23 6%
Immunology and Microbiology 16 4%
Other 35 9%
Unknown 79 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2022.
All research outputs
#2,088,789
of 25,373,627 outputs
Outputs from Genome Biology
#1,769
of 4,467 outputs
Outputs of similar age
#3,291
of 67,569 outputs
Outputs of similar age from Genome Biology
#3
of 18 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,569 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.