↓ Skip to main content

Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region

Overview of attention for article published in Epigenetics & Chromatin, April 2017
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)

Mentioned by

twitter
19 tweeters

Citations

dimensions_citation
18 Dimensions

Readers on

mendeley
54 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region
Published in
Epigenetics & Chromatin, April 2017
DOI 10.1186/s13072-017-0128-2
Pubmed ID
Authors

Lisa M. McEwen, Alexander M. Morin, Rachel D. Edgar, Julia L. MacIsaac, Meaghan J. Jones, William H. Dow, Luis Rosero-Bixby, Michael S. Kobor, David H. Rehkopf

Abstract

The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypothesized to be a component of biological aging, we focused on this malleable epigenetic mark to determine its association with current residence in Nicoya versus elsewhere in Costa Rica. Examining a population's unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation. These differences may be characteristic of a combination of social, biological, and environmental contexts. In a cross-sectional subsample of the Costa Rican Longevity and Healthy Aging Study, we compared whole blood DNA methylation profiles of residents from Nicoya (n = 48) and non-Nicoya (other Costa Rican regions, n = 47) using the Infinium HumanMethylation450 microarray. We observed a number of differences that may be markers of delayed aging, such as bioinformatically derived differential CD8+ T cell proportions. Additionally, both site- and region-specific analyses revealed DNA methylation patterns unique to Nicoyans. We also observed lower overall variability in DNA methylation in the Nicoyan population, another hallmark of younger biological age. Nicoyans represent an interesting group of individuals who may possess unique immune cell proportions as well as distinct differences in their epigenome, at the level of DNA methylation.

Twitter Demographics

The data shown below were collected from the profiles of 19 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 22%
Researcher 9 17%
Student > Ph. D. Student 8 15%
Student > Doctoral Student 4 7%
Student > Master 4 7%
Other 9 17%
Unknown 8 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 19%
Agricultural and Biological Sciences 8 15%
Nursing and Health Professions 5 9%
Medicine and Dentistry 5 9%
Social Sciences 3 6%
Other 12 22%
Unknown 11 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2021.
All research outputs
#2,489,674
of 21,174,193 outputs
Outputs from Epigenetics & Chromatin
#89
of 541 outputs
Outputs of similar age
#47,474
of 282,523 outputs
Outputs of similar age from Epigenetics & Chromatin
#1
of 1 outputs
Altmetric has tracked 21,174,193 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 541 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,523 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them