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Cellular polarity in aging: role of redox regulation and nutrition

Overview of attention for article published in Genes & Nutrition, December 2013
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4 X users
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1 Redditor

Citations

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18 Dimensions

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42 Mendeley
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Title
Cellular polarity in aging: role of redox regulation and nutrition
Published in
Genes & Nutrition, December 2013
DOI 10.1007/s12263-013-0371-5
Pubmed ID
Authors

Helena Soares, H. Susana Marinho, Carla Real, Fernando Antunes

Abstract

Cellular polarity concerns the spatial asymmetric organization of cellular components and structures. Such organization is important not only for biological behavior at the individual cell level, but also for the 3D organization of tissues and organs in living organisms. Processes like cell migration and motility, asymmetric inheritance, and spatial organization of daughter cells in tissues are all dependent of cell polarity. Many of these processes are compromised during aging and cellular senescence. For example, permeability epithelium barriers are leakier during aging; elderly people have impaired vascular function and increased frequency of cancer, and asymmetrical inheritance is compromised in senescent cells, including stem cells. Here, we review the cellular regulation of polarity, as well as the signaling mechanisms and respective redox regulation of the pathways involved in defining cellular polarity. Emphasis will be put on the role of cytoskeleton and the AMP-activated protein kinase pathway. We also discuss how nutrients can affect polarity-dependent processes, both by direct exposure of the gastrointestinal epithelium to nutrients and by indirect effects elicited by the metabolism of nutrients, such as activation of antioxidant response and phase-II detoxification enzymes through the transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2). In summary, cellular polarity emerges as a key process whose redox deregulation is hypothesized to have a central role in aging and cellular senescence.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
France 1 2%
South Africa 1 2%
United Kingdom 1 2%
Poland 1 2%
Unknown 37 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 26%
Researcher 6 14%
Student > Bachelor 4 10%
Student > Master 4 10%
Professor > Associate Professor 3 7%
Other 7 17%
Unknown 7 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 45%
Medicine and Dentistry 4 10%
Biochemistry, Genetics and Molecular Biology 4 10%
Chemistry 3 7%
Mathematics 1 2%
Other 5 12%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2021.
All research outputs
#14,017,769
of 24,178,331 outputs
Outputs from Genes & Nutrition
#191
of 401 outputs
Outputs of similar age
#170,611
of 316,506 outputs
Outputs of similar age from Genes & Nutrition
#4
of 14 outputs
Altmetric has tracked 24,178,331 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 401 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,506 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.