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Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3’-O-substituted carbonic ether moiety as potential antitumor agents

Overview of attention for article published in BMC Chemistry, December 2013
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Title
Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3’-O-substituted carbonic ether moiety as potential antitumor agents
Published in
BMC Chemistry, December 2013
DOI 10.1186/1752-153x-7-179
Pubmed ID
Authors

Mingyi Ma, Longru Sun, Hongxiang Lou, Mei Ji

Abstract

Combretastatin A-4 (CA-4), which is an excellent antineoplastic agent, was isolated from Combretum caffrum. To date, structural modification studies of CA-4 have focused predominantly on the construction of new therapeutic agents for drug discovery. As a part of our ongoing work towards the modification of natural products, we have focused on the 3'-O-substituent groups in the B-ring of CA-4 under the hypothesis that these novel derivatives will possess good bioactivities and behave as effective antiproliferative pro-drugs.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
India 1 3%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 18%
Student > Master 5 13%
Student > Bachelor 4 10%
Student > Ph. D. Student 4 10%
Professor 2 5%
Other 6 15%
Unknown 11 28%
Readers by discipline Count As %
Chemistry 18 46%
Agricultural and Biological Sciences 3 8%
Biochemistry, Genetics and Molecular Biology 2 5%
Social Sciences 2 5%
Medicine and Dentistry 1 3%
Other 1 3%
Unknown 12 31%