↓ Skip to main content

Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health

Overview of attention for article published in BMC Microbiology, April 2017
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#19 of 2,797)
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

news
4 news outlets
blogs
3 blogs
twitter
11 tweeters

Citations

dimensions_citation
227 Dimensions

Readers on

mendeley
354 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health
Published in
BMC Microbiology, April 2017
DOI 10.1186/s12866-017-1012-8
Pubmed ID
Authors

Asad U. Khan, Lubna Maryam, Raffaele Zarrilli

Abstract

The emergence of carbapenemase producing bacteria, especially New Delhi metallo-β-lactamase (NDM-1) and its variants, worldwide, has raised amajor public health concern. NDM-1 hydrolyzes a wide range of β-lactam antibiotics, including carbapenems, which are the last resort of antibiotics for the treatment of infections caused by resistant strain of bacteria. In this review, we have discussed bla NDM-1variants, its genetic analysis including type of specific mutation, origin of country and spread among several type of bacterial species. Wide members of enterobacteriaceae, most commonly Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and gram-negative non-fermenters Pseudomonas spp. and Acinetobacter baumannii were found to carry these markers. Moreover, at least seventeen variants of bla NDM-type gene differing into one or two residues of amino acids at distinct positions have been reported so far among different species of bacteria from different countries. The genetic and structural studies of these variants are important to understand the mechanism of antibiotic hydrolysis as well as to design new molecules with inhibitory activity against antibiotics. This review provides a comprehensive view of structural differences among NDM-1 variants, which are a driving force behind their spread across the globe.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 354 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 <1%
Unknown 353 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 59 17%
Student > Ph. D. Student 48 14%
Student > Bachelor 46 13%
Researcher 39 11%
Student > Doctoral Student 24 7%
Other 56 16%
Unknown 82 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 78 22%
Immunology and Microbiology 60 17%
Agricultural and Biological Sciences 35 10%
Medicine and Dentistry 32 9%
Chemistry 22 6%
Other 30 8%
Unknown 97 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2020.
All research outputs
#479,575
of 18,780,663 outputs
Outputs from BMC Microbiology
#19
of 2,797 outputs
Outputs of similar age
#12,944
of 276,097 outputs
Outputs of similar age from BMC Microbiology
#1
of 1 outputs
Altmetric has tracked 18,780,663 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,797 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,097 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them