Title |
CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers
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Published in |
Biomarker Research, June 2013
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DOI | 10.1186/2050-7771-1-22 |
Pubmed ID | |
Authors |
John J Kim, Krithika Rajagopalan, Basil Hussain, Brenten H Williams, Prakash Kulkarni, Steven M Mooney |
Abstract |
The Cancer Testis Antigens (CTAs) are a group of genes that are highly expressed in the normal testis and several types of cancer. Due to their restricted expression in normal adult tissues, CTAs have been attractive targets for immunotherapy and biomarker development. In this work, we discovered that Centrin 1 (CETN1) which is found in the centrosome of all eukaryotes, may be a member of this group and is highly expressed in prostate and pancreatic cancer. Three members of the centrin family of calcium binding proteins (CETN) are localized to the centrosome in all eukaryotes with CDC31 being the sole yeast homolog. CETN1 is a retrogene that probably arose from a retrotransposition of CETN2, an X-linked gene. A previous mouse study shows that CETN1 is expressed solely in the testis, while CETN2 is expressed in all organs. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 35% |
Researcher | 6 | 30% |
Student > Bachelor | 2 | 10% |
Lecturer | 1 | 5% |
Student > Master | 1 | 5% |
Other | 1 | 5% |
Unknown | 2 | 10% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 7 | 35% |
Biochemistry, Genetics and Molecular Biology | 6 | 30% |
Medicine and Dentistry | 3 | 15% |
Chemistry | 1 | 5% |
Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 2 | 10% |