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CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers

Overview of attention for article published in Biomarker Research, June 2013
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Title
CETN1 is a cancer testis antigen with expression in prostate and pancreatic cancers
Published in
Biomarker Research, June 2013
DOI 10.1186/2050-7771-1-22
Pubmed ID
Authors

John J Kim, Krithika Rajagopalan, Basil Hussain, Brenten H Williams, Prakash Kulkarni, Steven M Mooney

Abstract

The Cancer Testis Antigens (CTAs) are a group of genes that are highly expressed in the normal testis and several types of cancer. Due to their restricted expression in normal adult tissues, CTAs have been attractive targets for immunotherapy and biomarker development. In this work, we discovered that Centrin 1 (CETN1) which is found in the centrosome of all eukaryotes, may be a member of this group and is highly expressed in prostate and pancreatic cancer. Three members of the centrin family of calcium binding proteins (CETN) are localized to the centrosome in all eukaryotes with CDC31 being the sole yeast homolog. CETN1 is a retrogene that probably arose from a retrotransposition of CETN2, an X-linked gene. A previous mouse study shows that CETN1 is expressed solely in the testis, while CETN2 is expressed in all organs.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 35%
Researcher 6 30%
Student > Bachelor 2 10%
Lecturer 1 5%
Student > Master 1 5%
Other 1 5%
Unknown 2 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 35%
Biochemistry, Genetics and Molecular Biology 6 30%
Medicine and Dentistry 3 15%
Chemistry 1 5%
Engineering 1 5%
Other 0 0%
Unknown 2 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2013.
All research outputs
#15,288,160
of 22,736,112 outputs
Outputs from Biomarker Research
#156
of 310 outputs
Outputs of similar age
#121,852
of 196,917 outputs
Outputs of similar age from Biomarker Research
#1
of 2 outputs
Altmetric has tracked 22,736,112 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 310 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,917 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them